• 16-Nov-2018 to 15-Dec-2018 (EST)
  • Mississauga, ON, CAN
  • Microbix

The Manufacturing Technician is a production team member who will perform operations for production of viral and bacterial antigens.  This Manufacturing Technician position will focus on the culture, collection and processing of antigen and protein products.


Microbix logo

Our client, Microbix, is a fast growing biotechnology company based in Mississauga.


Founded in 1988 as a producer of infectious disease antigens, primarily for the diagnostics market, Microbix invests in the virology business to build capacity and develop new products to address emerging market opportunities, while enhancing manufacturing and laboratory capabilities and technologies.


Building on expertise in virology and protein biochemistry, the Microbix developed a pipeline of selected biological technologies including VIRUSMAX (Influenza Virus Yield Enhancement Technology), LumiSort (Semen Sexing Technology) and the thrombolytic drug, Kinlytic (Urokinase).


Our emerging products take aim at large market opportunities. With Microbix' core competencies in the Diagnostics business, including cell culture, molecular biology, and GMP quality system, these new products build on Microbix' strength.


Primary Function:

  • Individually and in conjunction with other members of the manufacturing culture team, perform cell and seed revival, scale up and culture of bulk quantities of viral antigens.
  • Individually and in conjunction with other members of the manufacturing processing team, participate in antigen collection and purification.
  • Perform equipment function checks, preventative maintenance, standardization and calibration of MFG equipment and components (pumps and probes);
  • Routine assembly, operation and sanitization of equipment, including single use and autoclavable vessels.
  • Monitor cell culture and viral performance through microscopic observation.
  • Prepares sterile buffers and reagents according to written procedures to support culture activities
  • Adhere to good manufacturing practices with accurate and concise document reporting. Complete documentation such as batch records, reports and non-conformance documents factually, accurately and on a timely basis.


Education / Knowledge:

  • Minimum Bachelor's Degree in a scientific discipline involving mammalian or microorganism culture.
  • College diploma in a related field with minimum 5 years' industrial experience.



  • Preference given to candidates with a proven track record in a GMP environment and experience in:
  • Large scale production and filtration/sterilization of cell culture media and the associated reagents.
  • Cryopreservation and Revival of cells from liquid nitrogen and Culture of various cell lines including but not limited to Vero, Ma104, MRC-5, FRhK4 and L cells (including both adherent mammalian cell culture and suspension cultures).
  • Bioreactor and / or chromatography experience in the industrial setting is an asset.
  • Strong proficiency in molecular and cellular biology, virology and engineering principles, techniques and demonstrated abilities in applying that knowledge.
  • Scientific knowledge and demonstrated hands-on experience in cell culture technologies applied to viral production.
  • Demonstrated ability to follow established guidelines and protocols and to complete work assignments in effective and efficient manner.
  • Effectively and reliably identifies and reports any non-conformances.
  • Strong communication and organization skills; be able to multi-task; be highly self-motivated, flexible, be able to collaborate and work effectively in teams.


Responsibilities / Skills / Competencies:

  • Reports to and works under minimum technical direction from the Manufacturing Supervisor.
  • Supports the team lead and supervisors in monitoring cultures to verify they meet batch record requirements and to assist with processing problem prevention and/or trouble shooting as required.
  • Ability to multi-task and prioritize job assignments.
  • Good math and computer skills.
  • Accurately maintains stocks of purification reagents and raw materials during product scale up and purification.
  • Completes documentation such as batch records, reports and non-conformance documents factually, accurately and on a timely basis.  Adheres to GMP and safety procedures.
  • An effective communicator with team members, supervisors and the Production Manager.
  • Actively participates in summary meetings and troubleshooting activities.
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